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Peptides — Metabolic

5-Amino-1MQ

A small-molecule selective inhibitor of nicotinamide N-methyltransferase (NNMT) studied in pre-clinical metabolic models.

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Pre-clinical mechanism

Selective NNMT inhibition raises intracellular S-adenosylmethionine (SAM) and nicotinamide pools in adipocytes, with downstream effects on adipogenesis and energy expenditure in rodent studies.

Key pre-clinical findings

  • Diet-induced obese mice: reduction in fat mass without changes in food intake (Neelakantan et al., 2018).

Primary literature

Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet–induced obesity

Neelakantan H, Vance V, Wetzel MD, et al. · Biochemical Pharmacology · 2018

Research and educational use only. This page summarises publicly available pre-clinical literature for educational and scientific reference. It is not medical, clinical, dosing or therapeutic advice. Nothing on this page implies that any VCP Australia product is approved, certified, safe, effective, suitable for a particular purpose, or intended for human or animal consumption.

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