Pre-clinical mechanism
Cell-culture studies describe binding to the FPR2 and CNTFR-WSX-1-gp130 receptor complex and activation of STAT3, with anti-apoptotic effects in neuronal models.
Key pre-clinical findings
- Cultured neurons exposed to amyloid-β: reduction in neurotoxicity and apoptotic markers (Hashimoto et al., 2001).
