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Peptides — Skin, Hair & Pigment

Melanotan II

A synthetic cyclic analogue of α-melanocyte stimulating hormone (α-MSH), studied in pre-clinical pigmentation and sexual-behaviour research.

MT-IIMT2

Education Hub

Pre-clinical mechanism

Non-selective agonist at melanocortin receptors (MC1R–MC5R). Animal models report melanogenesis through MC1R and central effects on appetite and sexual arousal via MC3R/MC4R.

Key pre-clinical findings

  • Original melanocortin pharmacology in frog skin and rodent assays established MT-II as a long-acting, super-potent α-MSH analogue (Hadley et al., 1989).

Primary literature

Discovery and development of novel melanogenic drugs — melanotan I and II

Hadley ME, Hruby VJ, Blanchard J, et al. · Pharmaceutical Biotechnology · 1998

Research and educational use only. This page summarises publicly available pre-clinical literature for educational and scientific reference. It is not medical, clinical, dosing or therapeutic advice. Nothing on this page implies that any VCP Australia product is approved, certified, safe, effective, suitable for a particular purpose, or intended for human or animal consumption.

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