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Peptides — Longevity & Mitochondrial

MOTS-c

A 16-amino-acid mitochondrial-derived peptide encoded by the 12S rRNA region of mtDNA, studied in metabolic and ageing research.

Education Hub

Pre-clinical mechanism

Animal and cell models describe activation of AMPK signalling, modulation of folate-methionine-AICAR flux, and effects on insulin sensitivity and exercise capacity.

Key pre-clinical findings

  • Aged mice: improved physical performance and metabolic markers versus saline controls (Reynolds et al., 2021).

Primary literature

MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis

Reynolds JC, Lai RW, Woodhead JST, et al. · Nature Communications · 2021

Research and educational use only. This page summarises publicly available pre-clinical literature for educational and scientific reference. It is not medical, clinical, dosing or therapeutic advice. Nothing on this page implies that any VCP Australia product is approved, certified, safe, effective, suitable for a particular purpose, or intended for human or animal consumption.

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