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Coenzymes & NAD Precursors

NAD+

A central redox coenzyme involved in electron transfer in glycolysis, the TCA cycle and oxidative phosphorylation, and a co-substrate for sirtuins, PARPs and CD38.

Nicotinamide Adenine Dinucleotide

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Pre-clinical mechanism

Cellular NAD+ levels decline with age in multiple tissues. Pre-clinical literature describes restoration of NAD+ pools improving sirtuin- and PARP-dependent processes in animal models.

Key pre-clinical findings

  • Aged-mouse studies: NAD+ restoration improved mitochondrial function and skeletal-muscle performance (Gomes et al., 2013).

Primary literature

Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging

Gomes AP, Price NL, Ling AJY, et al. · Cell · 2013

Research and educational use only. This page summarises publicly available pre-clinical literature for educational and scientific reference. It is not medical, clinical, dosing or therapeutic advice. Nothing on this page implies that any VCP Australia product is approved, certified, safe, effective, suitable for a particular purpose, or intended for human or animal consumption.

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