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Peptides — Growth Hormone Axis

Sermorelin

A synthetic peptide corresponding to amino acids 1-29 of human growth hormone-releasing hormone, the shortest fragment retaining full biological activity in animal pharmacology.

GRF (1-29)GHRH 1-29

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Pre-clinical mechanism

Binds the pituitary GHRH receptor and stimulates pulsatile endogenous GH release through the cAMP/PKA pathway.

Key pre-clinical findings

  • Animal pharmacology established GRF(1-29) as the minimum fully active fragment of native 44-amino-acid GHRH (Guillemin et al., 1982).

Primary literature

Growth hormone-releasing factor from a human pancreatic tumor

Guillemin R, Brazeau P, Böhlen P, et al. · Science · 1982

Research and educational use only. This page summarises publicly available pre-clinical literature for educational and scientific reference. It is not medical, clinical, dosing or therapeutic advice. Nothing on this page implies that any VCP Australia product is approved, certified, safe, effective, suitable for a particular purpose, or intended for human or animal consumption.

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