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Peptides — Longevity & Mitochondrial

SS-31 (Elamipretide)

A mitochondrial-targeted tetrapeptide that binds cardiolipin on the inner mitochondrial membrane, studied in pre-clinical mitochondrial-dysfunction models.

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Pre-clinical mechanism

Selective binding to cardiolipin stabilises cristae structure and improves electron-transport-chain efficiency in animal and isolated-mitochondria studies.

Key pre-clinical findings

  • Aged-mouse skeletal muscle: restored mitochondrial coupling and improved fatigue resistance (Siegel et al., 2013).

Primary literature

Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice

Siegel MP, Kruse SE, Percival JM, et al. · Aging Cell · 2013

Research and educational use only. This page summarises publicly available pre-clinical literature for educational and scientific reference. It is not medical, clinical, dosing or therapeutic advice. Nothing on this page implies that any VCP Australia product is approved, certified, safe, effective, suitable for a particular purpose, or intended for human or animal consumption.

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