Pre-clinical mechanism
Methylcobalamin is the cytoplasmic active form supporting methionine synthase, while adenosylcobalamin supports mitochondrial methylmalonyl-CoA mutase. Deficiency impairs DNA synthesis and myelin maintenance.
Key pre-clinical findings
- Comprehensive clinical review of B12 metabolism, deficiency syndromes and laboratory assessment (Stabler, 2013).
Primary literature
Research and educational use only. This page summarises publicly available pre-clinical literature for educational and scientific reference. It is not medical, clinical, dosing or therapeutic advice. Nothing on this page implies that any VCP Australia product is approved, certified, safe, effective, suitable for a particular purpose, or intended for human or animal consumption.